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KMID : 0043320070300091067
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Archives of Pharmacal Research
2007 Volume.30 No. 9 p.1067 ~ p.1074
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Lignan and Terpene Constituents from the Aerial Parts of Saussurea pulchella
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Yang Min-Cheol
Lee Kyu-Ha
Kim Ki-Hyun
Choi Sang-Un
Lee Kang-Ro
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Abstract
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Chromatographic separation of the MeOH extract from the aerial parts of Saussurea pulchella led to the isolation of seven terpenes (1-4, 11-13), and eight phenolics (5-10, 14-15). Their structures were determined by spectroscopic means to be (3S)-3-O-(3’,4’-diangeloyl-β-D-glucopyranosyloxy)- 3,7-trimethylocta-1,6-diene (1), 7δ-methoxy-4(14)-oppositen-1β-ol (2) 4(15)- eudesmene-1β,6α-diol (3), 3α-hydroxy-5, 6-epoxy-7-megastigmen-9-one (4), (+)-syringaresinol (5), (7S, 8R, 8’R)-5,5’-dimethoxylariciresinol (6), 8α-hydroxypinoresinol (7), (7’R, 8’R)-2,2’- dimethoxy-4-(3-hydroxyl-propenyl)-4’-(1,2,3-trihydroxypropyl)-biphenyl ether (8), 4-allyl-2,6- dimethoxyphenyl glucoside (9), 2-methoxy-4-(2-propenyl)phenyl β-D-glucoside (10), (-)-oplopan- 4-one-10α-O-β-D-glucoside (11), linalyl-O-β-D-glucoside (12), amarantholidoside IV (13), (+)-1-hydroxypinoresinol 1-O-β-D-glucoside (14), and syringin (15). Compounds 1-3 and 8-13 were first isolated from the genus Saussurea. The isolated compounds were examined for cytotoxic activity against four human cancer cell lines in vitro using the sulforhodamin B bio assay method
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KEYWORD
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Saussurea pulchella, Phenolics and Terpene, Cytotoxicity
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